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A New Site of Action

healthy wheat crop close up

Inatreq™ active is the first member of a new class of cereal fungicides, the picolinamides. It is a Quinone Inside Inhibitor (Qil) and inhibits mitochondrial respiration in fungi by blocking electron transfer in the respiratory chain, binds to complex III (the bc1 complex) at the Qi site (the inner mitochondrial membrane).

Inatreq offers a new solution for control of Septoria tritici where resistance to other chemistries (e.g. strobilurins and triazoles) is a concern.

Inatreq is best used as a protectant treatment or in the earliest stages of disease development.

Inhibition of fungal mitochondrial respiration results in a reduction in the amount of ATP (Adenosintriphosphate) produced. As ATP is the main chemical energy carrier that drives the vital functions of cells, key biochemical processes are distrupted, growth is inhibited and the fungus dies. 

Resistance Management

The unique target site of Inatreq™ active will be an innovative and effective tool in managing resistance when growers' choices are limited. Target site differs from all other current Septoria actives in the cereal market. 

Inatreq™ forms a tenacious deposit on the plant surface. It penetrates into the leaves in small but biologically active quantities. Once in the plant tissue, Inatreq is converted back to the natural product from which it is derived.

Based upon field trials, the following diseases will be controlled effectively by Inatreq at anticipated label use rates.

  • Very strong residual protectant efficacy in wheat against Septoria tritici with activity on Puccinia striiformis, Puccinia recondita and Helminthosporium tritici-repentis
  • Curative activity against Septoria tritici
  • Shows no cross-resistance to existing cereal fungicide chemistries
  • Compatible with other actives for tank mix flexibility

 

Toxicology

Laboratory tests show no unreasonable adverse effects from Inatreq™ active:

  • Not genotoxic
  • Not immunotoxic
  • Not neurotoxic
  • Not carcinogenic
  • Not a developmental toxicant
  • Not a reproductive hazard

Testing of Inatreq also indicates that the active ingredient exhibits very low acute toxicity to terrestrial species: mammals, birds, honeybees and earthworms.